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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases. Here, the synthesis of new compounds in which a hydroxamic...

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Principais autores: Virginija Jakubkiene, Gabrielius Ernis Valiulis, Markus Schweipert, Asta Zubriene, Daumantas Matulis, Franz-Josef Meyer-Almes, Sigitas Tumkevicius
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2022-07-01
coleção:Beilstein Journal of Organic Chemistry
Assuntos:
alkylation
aminolysis
hdac inhibitors
hydroxamic acid
pyrimidine
Acesso em linha:https://doi.org/10.3762/bjoc.18.84
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