Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape from human adaptive immunity resulting in significant morbidity and mortality in humans. Therefore, to avoid the need for annual reformulation and readministration of seasonal influenza virus vaccines, we are...

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Principais autores:	Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Alicia Solórzano, Francesco Berlanda-Scorza, Adolfo García-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-04-01
Series:	Frontiers in Immunology
Assuntos:	universal influenza virus vaccine live-attenuated influenza vaccine ferret stalk antibody chimeric hemagglutinin heterosubtypic protection
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00756/full
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