Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape from human adaptive immunity resulting in significant morbidity and mortality in humans. Therefore, to avoid the need for annual reformulation and readministration of seasonal influenza virus vaccines, we are...

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Autori principali:	Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Alicia Solórzano, Francesco Berlanda-Scorza, Adolfo García-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2019-04-01
Serie:	Frontiers in Immunology
Soggetti:	universal influenza virus vaccine live-attenuated influenza vaccine ferret stalk antibody chimeric hemagglutinin heterosubtypic protection
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00756/full
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