Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for <italic toggle="yes">In Vivo</italic> Protection in a Serum Transfer Mouse Challenge Model

ABSTRACT The immunogenicity of current influenza virus vaccines is assessed by measuring an increase of influenza virus-specific antibodies in a hemagglutination inhibition assay. This method exclusively measures antibodies against the hemagglutinin head domain. While this domain is immunodominant,...

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Hlavní autoři:	Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2017-11-01
Edice:	mBio
Témata:	ADCC ELISA correlate of protection hemagglutinin hemagglutinin stalk influenza
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.01463-17
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