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Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis

ABSTRACT Many viruses activate cellular autophagy in infected cells to facilitate their replication. Recently, we identified an interferon (IFN)-stimulated gene (ISG) Tudor domain containing 7 (TDRD7), which inhibits viral replication by blocking autophagy pathway. Here, we present a molecular mecha...

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Huvudupphov: Sukanya Chakravarty, Gayatri Subramanian, Sonam Popli, Manoj Veleeparambil, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology 2023-10-01
Serie:mBio
Ämnen:
Innate immunity
interferon
ISGs
TDRD7
AMPK
autophagy
Länkar:https://journals.asm.org/doi/10.1128/mbio.00611-23
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