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Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis

ABSTRACT Many viruses activate cellular autophagy in infected cells to facilitate their replication. Recently, we identified an interferon (IFN)-stimulated gene (ISG) Tudor domain containing 7 (TDRD7), which inhibits viral replication by blocking autophagy pathway. Here, we present a molecular mecha...

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Autori principali: Sukanya Chakravarty, Gayatri Subramanian, Sonam Popli, Manoj Veleeparambil, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2023-10-01
Serie:mBio
Soggetti:
Innate immunity
interferon
ISGs
TDRD7
AMPK
autophagy
Accesso online:https://journals.asm.org/doi/10.1128/mbio.00611-23
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