Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
Abstract Background Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 i...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2016-03-01
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| Series: | Journal of Hematology & Oncology |
| Assuntos: | |
| Acceso en liña: | http://link.springer.com/article/10.1186/s13045-016-0252-7 |
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