Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia

Congenital leukemia is a rare event with a poor prognosis. We report a case of congenital leukemia with a cryptic rearrangement of MLL demonstrable only with RT-PCR. Interestingly, with treatment, the patient showed lineage plasticity of the leukemia with the development of monocytic lineage blasts...

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Detalhes bibliográficos

Principais autores:	Elizabeth Moschiano, Gordana Raca, Cecilia Fu, Paul K. Pattengale, Mathew J. Oberley
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-01-01
coleção:	Leukemia Research Reports
Assuntos:	Congenital leukemia MLL rearrangement Lineage switch MPAL
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221304891630005X
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