Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma

Abstract Middle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss. Surgical resection is currently the only curative treatment, but the high recurr...

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Bibliografski detalji

Glavni autori:	Tomomi Yamamoto-Fukuda, Naotaro Akiyama, Hiromi Kojima
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-01-01
Serija:	Scientific Reports
Teme:	Menin-MLL inhibitors Drug development Histone modification c-MYC Middle ear cholesteatoma Keratinocyte growth factor
Online pristup:	https://doi.org/10.1038/s41598-025-34922-3
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