Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Abstract Background Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 i...

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Үндсэн зохиолчид:	Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo, Yongcheng Song
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2016-03-01
Цуврал:	Journal of Hematology & Oncology
Нөхцлүүд:	MLL-rearranged leukemia Lysine-specific demethylase 1 Enzyme inhibitor Drug discovery Leukemia therapeutics
Онлайн хандалт:	http://link.springer.com/article/10.1186/s13045-016-0252-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!