Inhibition of fibrin polymerization by synthetic peptides corresponding to Аα195-205 and γ69-77 sites of fibrin molecule

Using the idea of “proline brackets” we have found four sites in fibrin amino acid sequence, and appropriate peptides were synthesized: γ69NPDESSKPN77, Bβ228QPDSSVKPY236, Bβ455RPFFPQ460 and Aα195LPSRDRQHLPL205. Turbidity and electron-microscopy analyses have demonstrated that synthetic peptide Аα195...

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Hlavní autoři:	T. A. Pozniak, L. P. Urvant, P. G. Gritsenko, V. I. Chernishov, N. A. Pydiura, E. V. Lugovskoi, S. V. Komisarenko
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2014-08-01
Edice:	The Ukrainian Biochemical Journal
Témata:	inhibitors peptides proline brackets sites of fibrin polymerization
On-line přístup:	http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Pozniak_4_14.pdf
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