RECON-Dependent Inflammation in Hepatocytes Enhances <named-content content-type="genus-species">Listeria monocytogenes</named-content> Cell-to-Cell Spread

ABSTRACT The oxidoreductase RECON is a high-affinity cytosolic sensor of bacterium-derived cyclic dinucleotides (CDNs). CDN binding inhibits RECON’s enzymatic activity and subsequently promotes inflammation. In this study, we sought to characterize the effects of RECON on the infection cycle of the...

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Bibliografische Detailangaben

Hauptverfasser:	Adelle P. McFarland, Thomas P. Burke, Alexie A. Carletti, Rochelle C. Glover, Hannah Tabakh, Matthew D. Welch, Joshua J. Woodward
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2018-07-01
Schriftenreihe:	mBio
Schlagworte:	CDNs Listeria monocytogenes NF-κB RECON actin-based motility cyclic di-AMP
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.00526-18
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