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RECON-Dependent Inflammation in Hepatocytes Enhances <named-content content-type="genus-species">Listeria monocytogenes</named-content> Cell-to-Cell Spread

ABSTRACT The oxidoreductase RECON is a high-affinity cytosolic sensor of bacterium-derived cyclic dinucleotides (CDNs). CDN binding inhibits RECON’s enzymatic activity and subsequently promotes inflammation. In this study, we sought to characterize the effects of RECON on the infection cycle of the...

Deskribapen osoa

Gorde:
Egile Nagusiak: Adelle P. McFarland, Thomas P. Burke, Alexie A. Carletti, Rochelle C. Glover, Hannah Tabakh, Matthew D. Welch, Joshua J. Woodward
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2018-07-01
Saila:mBio
Gaiak:
CDNs
Listeria monocytogenes
NF-κB
RECON
actin-based motility
cyclic di-AMP
Sarrera elektronikoa:https://journals.asm.org/doi/10.1128/mBio.00526-18
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