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RECON-Dependent Inflammation in Hepatocytes Enhances <named-content content-type="genus-species">Listeria monocytogenes</named-content> Cell-to-Cell Spread

ABSTRACT The oxidoreductase RECON is a high-affinity cytosolic sensor of bacterium-derived cyclic dinucleotides (CDNs). CDN binding inhibits RECON’s enzymatic activity and subsequently promotes inflammation. In this study, we sought to characterize the effects of RECON on the infection cycle of the...

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Principais autores: Adelle P. McFarland, Thomas P. Burke, Alexie A. Carletti, Rochelle C. Glover, Hannah Tabakh, Matthew D. Welch, Joshua J. Woodward
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018-07-01
Serier:mBio
Fag:
CDNs
Listeria monocytogenes
NF-κB
RECON
actin-based motility
cyclic di-AMP
Online adgang:https://journals.asm.org/doi/10.1128/mBio.00526-18
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