Allosteric regulation of autoinhibition and activation of c-Abl
c-Abl, a non-receptor tyrosine kinase, regulates cell growth and survival in healthy cells and causes chronic myeloid leukemia (CML) when fused by Bcr. Its activity is blocked in the assembled inactive state, where the SH3 and SH2 domains dock into the kinase domain, reducing its conformational flex...
Na minha lista:
| Principais autores: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science (AAAS)
2022-01-01
|
| coleção: | Computational and Structural Biotechnology Journal |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2001037022003488 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|