Allosteric regulation of autoinhibition and activation of c-Abl

c-Abl, a non-receptor tyrosine kinase, regulates cell growth and survival in healthy cells and causes chronic myeloid leukemia (CML) when fused by Bcr. Its activity is blocked in the assembled inactive state, where the SH3 and SH2 domains dock into the kinase domain, reducing its conformational flex...

全面介紹

書目詳細資料

Principais autores:	Yonglan Liu, Mingzhen Zhang, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov
格式:	Artigo
語言:	Inglês
出版:	American Association for the Advancement of Science (AAAS) 2022-01-01
叢編:	Computational and Structural Biotechnology Journal
主題:	Allostery Kinase Chronic myeloid leukemia Bcr-Abl Allosteric drug Molecular dynamics
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2001037022003488
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!