The quaternary assembly of KRas4B with Raf-1 at the membrane
Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK) signaling. Among Ras isoforms, KRas4B is the most frequently mutated. Recent data on the binary KRas4B–Raf-1 complex suggested that Raf-1 CRD not only executes m...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Association for the Advancement of Science (AAAS)
2020-01-01
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| Edice: | Computational and Structural Biotechnology Journal |
| Témata: | |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S2001037020300301 |
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