Allosteric regulation of autoinhibition and activation of c-Abl
c-Abl, a non-receptor tyrosine kinase, regulates cell growth and survival in healthy cells and causes chronic myeloid leukemia (CML) when fused by Bcr. Its activity is blocked in the assembled inactive state, where the SH3 and SH2 domains dock into the kinase domain, reducing its conformational flex...
Uloženo v:
| Hlavní autoři: | , , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Association for the Advancement of Science (AAAS)
2022-01-01
|
| Edice: | Computational and Structural Biotechnology Journal |
| Témata: | |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S2001037022003488 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|