Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the mechanism throug...

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Bibliografiske detaljer

Principais autores:	Chunting Zhang, Steven T. Gossert, Jonathan Williams, Michael Little, Marilia Barros, Barton Dear, Bradley Falk, Ankit D. Kanthe, Robert Garmise, Luciano Mueller, Andrew Ilott, Anuji Abraham
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2023-12-01
Serier:	mAbs
Fag:	Excipient ranking mab stability mab–excipient interaction molecular dynamics Monte carlo STD NMR
Online adgang:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2212416
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