Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism

ABSTRACT Female sex increases risk of Group I pulmonary arterial hypertension by roughly threefold, but the mechanism is unclear. Low expression of Cyp1b1, an enzyme that metabolizes estrogens, is associated with disease penetrance, particularly in women. We previously found that lower Pparγ levels...

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Bibliografske podrobnosti

Principais autores:	Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James West
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-01-01
Serija:	Pulmonary Circulation
Teme:	Cyp1b1 estrogen metabolism PParg pulmonary hypertension
Online dostop:	https://doi.org/10.1002/pul2.70054
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