Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism

ABSTRACT Female sex increases risk of Group I pulmonary arterial hypertension by roughly threefold, but the mechanism is unclear. Low expression of Cyp1b1, an enzyme that metabolizes estrogens, is associated with disease penetrance, particularly in women. We previously found that lower Pparγ levels...

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Autores principales:	Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James West
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-01-01
Colección:	Pulmonary Circulation
Materias:	Cyp1b1 estrogen metabolism PParg pulmonary hypertension
Acceso en línea:	https://doi.org/10.1002/pul2.70054
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