Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review

Pulmonary arterial hypertension (PAH) is a progressive, currently incurable disease characterized by elevated pulmonary arterial pressure, vascular remodeling, and right ventricular hypertrophy, eventually leading to heart failure and death. Sirtuin 1 (SIRT1), a NAD⁺-dependent deacetylase...

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Principais autores:	Sandra Budziak, Monika Kloza, Anna Krzyżewska, Marta Baranowska-Kuczko
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-09-01
Series:	Molecules
Assuntos:	pulmonary hypertension pulmonary arterial hypertension sirtuin 1 pulmonary artery vascular smooth muscle cells pulmonary artery endothelial cells vascular remodeling
Acceso en liña:	https://www.mdpi.com/1420-3049/30/18/3740
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