Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway

Pulmonary hypertension (PH) is an extremely serious cardiopulmonary disease, finally leading to progressive right ventricular failure and death. Our previous studies have nominated HLQ2g, a pyrazolo[3,4-b] pyridine derivative stimulating soluble guanylate cyclase (sGC), as a new candidate for the tr...

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Bibliografische Detailangaben

Hauptverfasser:	Lijun Li, Minghui Yin, Liqing Hu, Xiaoting Tian, Xiangrong He, Congke Zhao, Ying Li, Qianbin Li, Xiaohui Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-10-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	pulmonary hypertension hypoxia cGKI BMP signaling pathway pulmonary artery smooth muscle cells
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2021.691405/full
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