High adenoviral vector concentration can cause irreversible aggregation during CsCl gradient ultracentrifugation

Highly purified adenovirus preparations are essential for fundamental research and therapeutic use. However, the impact of viral concentration during CsCl gradient ultracentrifugation on virion integrity is poorly understood, and this incomplete mechanistic understanding may adversely affect product...

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Hlavní autoři:	Haidong Wu, Ya-Fang Mei
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-06-01
Edice:	Frontiers in Microbiology
Témata:	adenovirus vectors chemical restoration EM morphology high concentration irreversible aggregation OD calculation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1845210/full
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