High adenoviral vector concentration can cause irreversible aggregation during CsCl gradient ultracentrifugation

Highly purified adenovirus preparations are essential for fundamental research and therapeutic use. However, the impact of viral concentration during CsCl gradient ultracentrifugation on virion integrity is poorly understood, and this incomplete mechanistic understanding may adversely affect product...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Haidong Wu, Ya-Fang Mei
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2026-06-01
Цуврал:	Frontiers in Microbiology
Нөхцлүүд:	adenovirus vectors chemical restoration EM morphology high concentration irreversible aggregation OD calculation
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1845210/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!