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In Vivo Tracking for Oncolytic Adenovirus Interactions with Liver Cells

Hepatotoxicity remains an as yet unsolved problem for adenovirus (Ad) cancer therapy. The toxic effects originate both from rapid Kupffer cell (KCs) death (early phase) and hepatocyte transduction (late phase). Several host factors and capsid components are known to contribute to hepatotoxicity, how...

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Autores principales: Victor A. Naumenko, Daniil A. Vishnevskiy, Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia A. Chernysheva, Tatiana O. Abakumova, Marat P. Valikhov, Anastasiia V. Lipatova, Maxim A. Abakumov, Vladimir P. Chekhonin
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2022-07-01
Colección:Biomedicines
Materias:
adenovirus
liver
hepatotoxicity
zeiosis
neutrophils
CD8+ T cells
Acceso en línea:https://www.mdpi.com/2227-9059/10/7/1697
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