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In Vivo Tracking for Oncolytic Adenovirus Interactions with Liver Cells

Hepatotoxicity remains an as yet unsolved problem for adenovirus (Ad) cancer therapy. The toxic effects originate both from rapid Kupffer cell (KCs) death (early phase) and hepatocyte transduction (late phase). Several host factors and capsid components are known to contribute to hepatotoxicity, how...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Victor A. Naumenko, Daniil A. Vishnevskiy, Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia A. Chernysheva, Tatiana O. Abakumova, Marat P. Valikhov, Anastasiia V. Lipatova, Maxim A. Abakumov, Vladimir P. Chekhonin
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-07-01
Schriftenreihe:Biomedicines
Schlagworte:
adenovirus
liver
hepatotoxicity
zeiosis
neutrophils
CD8+ T cells
Online-Zugang:https://www.mdpi.com/2227-9059/10/7/1697
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