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Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP). Using homology models developed from existing structural data and docking experiments, we have carried out all-a...

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Main Authors: Elisa Frezza, Tina-Méryl Amans, Juliette Martin
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
molecular dynamics
flexibility
protein-protein interactions
allostery
enzyme activity
docking
Online Access:https://www.mdpi.com/2218-273X/10/9/1330
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