Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP). Using homology models developed from existing structural data and docking experiments, we have carried out all-a...

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Detalhes bibliográficos

Principais autores:	Elisa Frezza, Tina-Méryl Amans, Juliette Martin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-09-01
coleção:	Biomolecules
Assuntos:	molecular dynamics flexibility protein-protein interactions allostery enzyme activity docking
Acesso em linha:	https://www.mdpi.com/2218-273X/10/9/1330
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