Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case

Abstract Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long terminal half‐life and accumulates in...

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Auteurs principaux:	Douglas G. Johns, Sheng‐Ping Wang, Raymond Rosa, James Hubert, Suoyu Xu, Ying Chen, Thomas Bateman, Robert O. Blaustein
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2019-12-01
Collection:	Pharmacology Research & Perspectives
Sujets:	adipose anacetrapib cholesteryl ester transfer protein pharmacokinetics
Accès en ligne:	https://doi.org/10.1002/prp2.543
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