Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case

Abstract Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long terminal half‐life and accumulates in...

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Hlavní autoři:	Douglas G. Johns, Sheng‐Ping Wang, Raymond Rosa, James Hubert, Suoyu Xu, Ying Chen, Thomas Bateman, Robert O. Blaustein
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2019-12-01
Edice:	Pharmacology Research & Perspectives
Témata:	adipose anacetrapib cholesteryl ester transfer protein pharmacokinetics
On-line přístup:	https://doi.org/10.1002/prp2.543
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