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Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case

Abstract Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long terminal half‐life and accumulates in...

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Principais autores: Douglas G. Johns, Sheng‐Ping Wang, Raymond Rosa, James Hubert, Suoyu Xu, Ying Chen, Thomas Bateman, Robert O. Blaustein
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2019-12-01
Serier:Pharmacology Research & Perspectives
Fag:
adipose
anacetrapib
cholesteryl ester transfer protein
pharmacokinetics
Online adgang:https://doi.org/10.1002/prp2.543
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