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Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Abstract Macrophages exhibit high plasticity in response to tubular epithelial cell (TEC) injury. Gasdermin D (GSDMD)‐mediated pyroptosis amplifies the inflammatory and fibrogenic cascade, yet its role in chronic kidney disease (CKD) remains elusive. Herein, GSDMD is upregulated in kidney macrophage...

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Principais autores: Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-02-01
coleção:Advanced Science
Assuntos:
gasdermin D
inflammation
macrophages
pyroptosis
renal fibrosis
Acesso em linha:https://doi.org/10.1002/advs.202512278
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