QR-kod

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Abstract Macrophages exhibit high plasticity in response to tubular epithelial cell (TEC) injury. Gasdermin D (GSDMD)‐mediated pyroptosis amplifies the inflammatory and fibrogenic cascade, yet its role in chronic kidney disease (CKD) remains elusive. Herein, GSDMD is upregulated in kidney macrophage...

Full beskrivning

Sparad:
Huvudupphov: Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao
Materialtyp: Artigo
Språk:Inglês
Utgiven: Wiley 2026-02-01
Serie:Advanced Science
Ämnen:
gasdermin D
inflammation
macrophages
pyroptosis
renal fibrosis
Länkar:https://doi.org/10.1002/advs.202512278
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk