Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Abstract Macrophages exhibit high plasticity in response to tubular epithelial cell (TEC) injury. Gasdermin D (GSDMD)‐mediated pyroptosis amplifies the inflammatory and fibrogenic cascade, yet its role in chronic kidney disease (CKD) remains elusive. Herein, GSDMD is upregulated in kidney macrophage...

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Auteurs principaux:	Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-02-01
Collection:	Advanced Science
Sujets:	gasdermin D inflammation macrophages pyroptosis renal fibrosis
Accès en ligne:	https://doi.org/10.1002/advs.202512278
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