Mechanistically Explainable AI Model for Predicting Synergistic Cancer Therapy Combinations

This study introduces a Large Language Model (LLM)-based framework that combines drug combination data with a knowledge graph to predict synergistic oncology drug combinations with mechanistic insights. Using a retrieval-augmented generation (RAG) approach, over 50,000 in vitro drug pair assay resul...

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Үндсэн зохиолчид:	Han Si, Sanyam Kumar, Sneh Lata, Arshad Ahmad, Saurav Ghosh, Karen Stephansen, Deepti Nagarkar, Eda Zhou, Brandon W. Higgs
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2025-09-01
Цуврал:	Current Oncology
Нөхцлүүд:	oncology Large Language Model (LLM) drug combination knowledge graph retrieval-augmented generation (RAG) clinical trial
Онлайн хандалт:	https://www.mdpi.com/1718-7729/32/10/548
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!