Mechanistically Explainable AI Model for Predicting Synergistic Cancer Therapy Combinations

This study introduces a Large Language Model (LLM)-based framework that combines drug combination data with a knowledge graph to predict synergistic oncology drug combinations with mechanistic insights. Using a retrieval-augmented generation (RAG) approach, over 50,000 in vitro drug pair assay resul...

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Hlavní autoři:	Han Si, Sanyam Kumar, Sneh Lata, Arshad Ahmad, Saurav Ghosh, Karen Stephansen, Deepti Nagarkar, Eda Zhou, Brandon W. Higgs
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-09-01
Edice:	Current Oncology
Témata:	oncology Large Language Model (LLM) drug combination knowledge graph retrieval-augmented generation (RAG) clinical trial
On-line přístup:	https://www.mdpi.com/1718-7729/32/10/548
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