Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate. We previously found that matrine, a major alkaloid in...

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Bibliografski detalji

Glavni autori:	Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2018-05-01
Serija:	Frontiers in Pharmacology
Teme:	matrine spinal cord injury axonal growth chondroitin sulfate proteoglycan DARTS heat shock protein 90
Online pristup:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00446/full
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