Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate. We previously found that matrine, a major alkaloid in...

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Автори:	Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2018-05-01
Серія:	Frontiers in Pharmacology
Предмети:	matrine spinal cord injury axonal growth chondroitin sulfate proteoglycan DARTS heat shock protein 90
Онлайн доступ:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00446/full
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