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Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate. We previously found that matrine, a major alkaloid in...

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Principais autores: Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-05-01
Serier:Frontiers in Pharmacology
Fag:
matrine
spinal cord injury
axonal growth
chondroitin sulfate proteoglycan
DARTS
heat shock protein 90
Online adgang:http://journal.frontiersin.org/article/10.3389/fphar.2018.00446/full
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