Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manifested irrespective of the concentration. Our aim i...

Descrición completa

Detalles Bibliográficos

Principais autores:	Krisztina Pesti, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Peter Lukacs, Arpad Mike
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Assuntos:	automated patch-clamp sodium channel inhibitor binding kinetics riluzole lidocaine benzocaine
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fphar.2021.738460/full
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!