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Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manifested irrespective of the concentration. Our aim i...

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Principais autores: Krisztina Pesti, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Peter Lukacs, Arpad Mike
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-08-01
Serier:Frontiers in Pharmacology
Fag:
automated patch-clamp
sodium channel inhibitor
binding kinetics
riluzole
lidocaine
benzocaine
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.738460/full
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