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The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium channels (VGSC) are inhibited within the same...

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Autori principali: Benjamin Hackl, Peter Lukacs, Janine Ebner, Krisztina Pesti, Nicholas Haechl, Mátyás C Földi, Elena Lilliu, Klaus Schicker, Helmut Kubista, Anna Stary-Weinzinger, Karlheinz Hilber, Arpad Mike, Hannes Todt, Xaver Koenig
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Pharmacology
Soggetti:
ivabradine
S16257
voltage-gated sodium channel
conduction cell
ventricular cardiomyocyte
atypical inhibitor
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2022.809802/full
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