Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase. For this reason, ligand-membrane interactions are as important determinants of inhibitor properties,...

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Principais autores:	Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Laszlo eFodor, Arpad eMike
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	antidepressant pH Automated Patch-Clamp lipophilicity sodium channel blocker Local anesthetic
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00210/full
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