Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase. For this reason, ligand-membrane interactions are as important determinants of inhibitor properties,...

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Hlavní autoři:	Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Laszlo eFodor, Arpad eMike
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2015-09-01
Edice:	Frontiers in Pharmacology
Témata:	antidepressant pH Automated Patch-Clamp lipophilicity sodium channel blocker Local anesthetic
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00210/full
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