Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

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Detalles Bibliográficos

Principais autores:	Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika
Formato:	Artigo
Idioma:	Inglês
Publicado:	Beilstein-Institut 2021-03-01
Series:	Beilstein Journal of Organic Chemistry
Assuntos:	artificial nucleic acid duplex-forming ability oligonucleotide synthesis
Acceso en liña:	https://doi.org/10.3762/bjoc.17.54
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