Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Beilstein-Institut 2021-03-01
Edice:	Beilstein Journal of Organic Chemistry
Témata:	artificial nucleic acid duplex-forming ability oligonucleotide synthesis
On-line přístup:	https://doi.org/10.3762/bjoc.17.54
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!