Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Beilstein-Institut 2021-03-01
Цуврал:	Beilstein Journal of Organic Chemistry
Нөхцлүүд:	artificial nucleic acid duplex-forming ability oligonucleotide synthesis
Онлайн хандалт:	https://doi.org/10.3762/bjoc.17.54
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!