Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

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Prif Awduron:	Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Beilstein-Institut 2021-03-01
Cyfres:	Beilstein Journal of Organic Chemistry
Pynciau:	artificial nucleic acid duplex-forming ability oligonucleotide synthesis
Mynediad Ar-lein:	https://doi.org/10.3762/bjoc.17.54
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!