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Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis

IntroductionMultiple sclerosis (MS) is a potentially disabling disease that damages the brain and spinal cord, inducing paralysis of the body. While MS has been known as a T-cell mediated disease, recent attention has been drawn to the involvement of B cells in its pathogenesis. Autoantibodies from...

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Main Authors: Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
sphingosylphosphorylcholine
plasma cells
S1PR3
experimental autoimmune encephalomyelitis
multiple sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151511/full
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